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(Journal Article) |
Journal of neuro-oncology 118 (3): 557-99 (2014)
The role of targeted therapies in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline.
Jeffrey J Olson
,
Lakshmi Nayak
,
D Ryan Ormond
,
Patrick Y Wen
,
Steven N Kalkanis
,
Timothy Charles Ryken
,
AANS/CNS Joint Guidelines Committee
ABSTRACT
What is the influence of targeted medical therapies on disease control and survival in the adult patient with progressive glioblastoma?This recommendation applies to adult patients with progressive glioblastomaLevel III Treatment with bevacizumab is recommended as it provides improved disease control compared to historical controls as measured by best imaging response and progression free survival at 6 months. Given that there are a large number of therapies are available for progressive glioblastoma that may be applied under selected circumstances dependent on patient characteristics and treating physician judgment, it is strongly recommended that patients with progressive glioblastoma be enrolled in properly designed clinical investigations to provide convincing evidence of therapeutic value.