Unrecognized pertussis infection in adolescents.

Cromer, B A; Goydos, J; Hackell, J; Mezzatesta, J; Dekker, C; Mortimer, E A

People

Help

CiteReady is an online personal knowledge management tool. Click to find out more!

James's Profile

James's Publications

Publicly Shared Collections

Shared by James Goydos

My Publications

Updated in 8/12/2020 12:04:22 PM

Viewed: 136 times

(Journal Article)

American journal of diseases of children (1960) 147 (5): 575-7 (1993)

Unrecognized pertussis infection in adolescents.

B A Cromer , J Goydos , J Hackell , J Mezzatesta , C Dekker , E A Mortimer

ABSTRACT
Little information is available regarding the level of immunity to Bordetella pertussis among adolescents. We measured serum antibodies in 156 healthy adolescents to the following pertussis antigens: pertussis toxin, filamentous hemagglutinin, and 69-kd outer membrane protein. In an attempt to identify intercurrent pertussis infections, we also obtained a total of 43 repeated samples during the following 5 years. Using a 50% or greater rise in IgG enzyme-linked immunosorbent assay titers to define seroconversion, we found an annual incidence of 6.1%; by alternative definitions of seropositivity, the predicted annual incidence of infection ranged from 1.2% to 8.2%. These data suggest that infection with B pertussis is common in the adolescent population.

DOI: 10.1001/archpedi.1993.02160290081031

ISSN: 0002-922X

Report this

Community
People

Position:	Professor
About me:	James Goydos, MD is widely recognized as an expert in melanoma research & surgical oncology. In his over 20 years of experience as a surgeon, he has conducted research that has translated into patient care, clinical trials, & cutting-edge treatment. His research and clinical trials have recorded growth arrest in melanoma cells, transforming the area of cancer genomics. Goydos has decades of experience as a Professor of Surgery and researcher at UMDNJ Robert Wood Johnson Medical School. He is an advocate for patient privacy and is recognized for leadership in patient care by the Cancer Institute of New Jersey and MRF. By 2020, his work in melanoma & innovative trials have led him to record numerous awards by Castle Connolly. He has helped individuals to better understand the mechanics of melanoma, the invasion of the dermis, and to see that it is not always a death sentence.
ORCID: