| Updated in 12/28/2021 4:14:09 PM |
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(Journal Article) |
Pathology, research and practice 216 (1): 152782 (2020)
The immune checkpoints CTLA-4 and PD-L1 in carcinomas of the uterine cervix.
Georgia Karpathiou
,
Celine Chauleur
,
Mousa Mobarki
,
Michel Peoc'h
ABSTRACT
Evasion of immune control is a major feature of malignant tumors. This tumor aspect is poorly studied in cervical lesions.To investigate the expression of PD-L1 and CTLA-4 in lesions of the uterine cervix.Sixty-three cervical lesions from 52 patients were immunohistochemically studied. The 63 lesions included 27 invasive adenocarcinomas, 19 squamous cell carcinomas (SCCs), 7 adenocarcinomas in situ, and 10 high-grade squamous intraepithelial lesions (CIN3).CTLA-4 and PD-L1 tumor cell expression was found in 61.5 % and 26.9 % of the invasive cases, respectively. CTLA-4 tumor cell expression and PD-L1 tumor and immune cell expression were more often found in SCCs than in adenocarcinomas. CTLA-4 tumor cell expression was more often found in advanced FIGO tumors. PD-L1 and CTLA-4 immune cell expression was associated with lymph node metastasis. CTLA-4 expression did not affect survival. The prognosis was worse for PD-L1-expressing tumors.CTLA-4 and PD-L1 are potential therapeutic targets in cervical cancer.