| Updated in 12/28/2021 4:11:08 PM |
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(Journal Article) |
Scientific reports 11 (1): 20708 (2021)
Vitamin D deficiency during late pregnancy mediates placenta-associated complications.
Tiphaine Raia-Barjat
,
Camille Sarkis
,
Florence Rancon
,
Lise Thibaudin
,
Jean-Christophe Gris
,
Nadia Alfaidy
,
Céline Chauleur
ABSTRACT
During pregnancy, maternal vitamin D insufficiency could increase the risk of preeclampsia. Aim of the study was to evaluate the relationship between vitamin D status and the occurrence of placenta-mediated complications (PMCs) in a population at high risk. A prospective multicenter cohort study of 200 pregnant patients was conducted. The vitamin D level of patients with placenta-mediated complications was lower at 32 weeks compared to uncomplicated pregnancies (P?=?0.001). At 32 weeks, the risk of occurrence of PMCs was five times higher in patients with vitamin D deficiency (RR: 5.14 95% CI (1.50-17.55)) compared to patients with normal vitamin D levels. There was a strong, inverse relationship between serum 25(OH)D levels at 32 weeks and the subsequent risk of PMCs (P?=?0.001). At 32 weeks, the vitamin D level of patients with late-onset PMCs was lower than the one of patients with early-onset PMCs and of patients without PMCs (P?