Updated in 2/6/2019 12:02:25 PM |
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(Journal Article) |
Pediatric pulmonology (2019)
Interleukin-4 -590C/T gene polymorphism in Egyptian children with acute lower respiratory infection: A multicenter study.
Ahmed A Emam
,
Mohamed M M Shehab
,
Mayy A N Allah
,
Mohamed A Elkoumi
,
NourEldin M Abdelaal
,
Amira A A Mosabah
,
Mervat T Zakaria
,
Ashraf M Sherif
,
Mohammed M Soliman
,
Rania M H El-Kaffas
,
Heba Abouzeid
,
Mohammed A Abdou
,
Nermin Abdalmonem
,
Heba R Abdelbaset
,
Soma A Mohamed
,
Attia A Soliman
,
Shaimaa S A Elashkar
,
Mohamed S Hegab
,
Atef M Khalil
,
Alsayed Abdel-Aziz
,
Heba G Anany
,
Hossam E Salah
,
Adel M Abdou
,
Naglaa A Elshehawy
,
Hany A A Elbasyouni
,
Sahbaa F M Hafez
,
Doaa A Abo-Alella
,
Maggie M Fawzi
,
Samar S Morsi
ABSTRACT
Acute lower respiratory infection (ALRI) is the leading cause of child mortality, especially in the developing world. Polymorphisms in the interleukin 4 (IL-4) gene have been linked to a variety of human diseases.To investigate whether the IL-4 -590C/T (rs2243250) polymorphism could be a genetic marker for susceptibility to ALRIs in young Egyptian children.This was a multicenter study conducted on 480 children diagnosed with pneumonia or bronchiolitis, and 480 well-matched healthy control children. Using PCR-RFLP analysis, we genotyped a -590C/T (rs2243250) single nucleotide polymorphism of the IL-4 gene promoter, meanwhile the serum IL-4concentration was measured by ELISA.The frequency of the IL-4 -590 T/T genotype and T allele were overrepresented in patients with ALRIs in comparison to the control group (OR = 2.0; [95% confidence interval [CI]: 1.38-2.96]; for the T/T genotype) and (OR: 1.3; [95%CI: 1.07-1.56]; for the T allele; P < 0.01). The IL-4 -590 T/T genotype was associated with significantly higher mean serum IL-4 concentration (58.7 ± 13.4 pg/mL) compared to the C/T genotype (47.6 ± 11 pg/mL) and the C/C genotype (34.8 ± 9.6 pg/mL); P < 0.01.The IL-4 -590C/T (rs2243250) polymorphism may contribute to susceptibility to ALRIs in young Egyptian children.