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Updated in 2/20/2022 4:03:19 PM      Viewed: 104 times      (Journal Article)
Journal of clinical research in pediatric endocrinology 5 (3): 206-8 (2013)

Neonatal seizure as a manifestation of unrecognized maternal hyperparathyroidism.

Hüseyin Anil Korkmaz , Behzat Ozkan , Demet Terek , Ceyhun Dizdarer , Sertaç Arslanoglu
Maternal hypercalcemia suppresses parathyroid activity in the fetus resulting in impaired parathyroid responsiveness to hypocalcemia after birth. Resultant hypocalcemia may be severe and prolonged and rarely may lead to convulsions. Here, we present a newborn infant admitted to the pediatric emergency department at age two weeks with recurrent tonic convulsions due to asymptomatic maternal hyperparathyroidism and vitamin D deficiency. Physicians should be aware that undiagnosed maternal hyperparathyroidism can cause severe hypocalcemia in the newborn.
DOI: 10.4274/Jcrpe.1037      ISSN: 1308-5727