CiteReady is an online personal knowledge management tool. Click to find out more!
 
Updated in 10/16/2022 6:38:16 PM      Viewed: 88 times      (Journal Article)
The American journal of clinical nutrition 103 (4): 1033-44 (2016)

Vitamin D deficiency in Europe: pandemic?

Kevin D Cashman , Kirsten G Dowling , Zuzana Škrabáková , Marcela Gonzalez-Gross , Jara Valtueña , Stefaan De Henauw , Luis Moreno , Camilla T Damsgaard , Kim F Michaelsen , Christian Mølgaard , Rolf Jorde , Guri Grimnes , George Moschonis , Christina Mavrogianni , Yannis Manios , Michael Thamm , Gert Bm Mensink , Martina Rabenberg , Markus A Busch , Lorna Cox , Sarah Meadows , Gail Goldberg , Ann Prentice , Jacqueline M Dekker , Giel Nijpels , Stefan Pilz , Karin M Swart , Natasja M van Schoor , Paul Lips , Gudny Eiriksdottir , Vilmundur Gudnason , Mary Frances Cotch , Seppo Koskinen , Christel Lamberg-Allardt , Ramon A Durazo-Arvizu , Christopher T Sempos , Mairead Kiely
ABSTRACT
Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys.This study applied VDSP protocols to serum 25(OH)D data from representative childhood/teenage and adult/older adult European populations, representing a sizable geographical footprint, to better quantify the prevalence of vitamin D deficiency in Europe.The VDSP protocols were applied in 14 population studies [reanalysis of subsets of serum 25(OH)D in 11 studies and complete analysis of all samples from 3 studies that had not previously measured it] by using certified liquid chromatography-tandem mass spectrometry on biobanked sera. These data were combined with standardized serum 25(OH)D data from 4 previously standardized studies (for a total n= 55,844). Prevalence estimates of vitamin D deficiency [using various serum 25(OH)D thresholds] were generated on the basis of standardized 25(OH)D data.An overall pooled estimate, irrespective of age group, ethnic mix, and latitude of study populations, showed that 13.0% of the 55,844 European individuals had serum 25(OH)D concentrations <30 nmol/L on average in the year, with 17.7% and 8.3% in those sampled during the extended winter (October-March) and summer (April-November) periods, respectively. According to an alternate suggested definition of vitamin D deficiency (<50 nmol/L), the prevalence was 40.4%. Dark-skinned ethnic subgroups had much higher (3- to 71-fold) prevalence of serum 25(OH)D <30 nmol/L than did white populations.Vitamin D deficiency is evident throughout the European population at prevalence rates that are concerning and that require action from a public health perspective. What direction these strategies take will depend on European policy but should aim to ensure vitamin D intakes that are protective against vitamin D deficiency in the majority of the European population.
DOI: 10.3945/ajcn.115.120873      ISSN: 0002-9165