Updated in 10/16/2022 6:38:16 PM |
Viewed: 73 times |
(Journal Article) |
The American journal of clinical nutrition 103 (4): 1033-44 (2016)
Vitamin D deficiency in Europe: pandemic?
Kevin D Cashman
,
Kirsten G Dowling
,
Zuzana Škrabáková
,
Marcela Gonzalez-Gross
,
Jara Valtueña
,
Stefaan De Henauw
,
Luis Moreno
,
Camilla T Damsgaard
,
Kim F Michaelsen
,
Christian Mølgaard
,
Rolf Jorde
,
Guri Grimnes
,
George Moschonis
,
Christina Mavrogianni
,
Yannis Manios
,
Michael Thamm
,
Gert Bm Mensink
,
Martina Rabenberg
,
Markus A Busch
,
Lorna Cox
,
Sarah Meadows
,
Gail Goldberg
,
Ann Prentice
,
Jacqueline M Dekker
,
Giel Nijpels
,
Stefan Pilz
,
Karin M Swart
,
Natasja M van Schoor
,
Paul Lips
,
Gudny Eiriksdottir
,
Vilmundur Gudnason
,
Mary Frances Cotch
,
Seppo Koskinen
,
Christel Lamberg-Allardt
,
Ramon A Durazo-Arvizu
,
Christopher T Sempos
,
Mairead Kiely
ABSTRACT
Vitamin D deficiency has been described as being pandemic, but serum 25-hydroxyvitamin D [25(OH)D] distribution data for the European Union are of very variable quality. The NIH-led international Vitamin D Standardization Program (VDSP) has developed protocols for standardizing existing 25(OH)D values from national health/nutrition surveys.This study applied VDSP protocols to serum 25(OH)D data from representative childhood/teenage and adult/older adult European populations, representing a sizable geographical footprint, to better quantify the prevalence of vitamin D deficiency in Europe.The VDSP protocols were applied in 14 population studies [reanalysis of subsets of serum 25(OH)D in 11 studies and complete analysis of all samples from 3 studies that had not previously measured it] by using certified liquid chromatography-tandem mass spectrometry on biobanked sera. These data were combined with standardized serum 25(OH)D data from 4 previously standardized studies (for a total n= 55,844). Prevalence estimates of vitamin D deficiency [using various serum 25(OH)D thresholds] were generated on the basis of standardized 25(OH)D data.An overall pooled estimate, irrespective of age group, ethnic mix, and latitude of study populations, showed that 13.0% of the 55,844 European individuals had serum 25(OH)D concentrations <30 nmol/L on average in the year, with 17.7% and 8.3% in those sampled during the extended winter (October-March) and summer (April-November) periods, respectively. According to an alternate suggested definition of vitamin D deficiency (<50 nmol/L), the prevalence was 40.4%. Dark-skinned ethnic subgroups had much higher (3- to 71-fold) prevalence of serum 25(OH)D <30 nmol/L than did white populations.Vitamin D deficiency is evident throughout the European population at prevalence rates that are concerning and that require action from a public health perspective. What direction these strategies take will depend on European policy but should aim to ensure vitamin D intakes that are protective against vitamin D deficiency in the majority of the European population.