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(Journal Article) |
The New England journal of medicine 345 (19): 1368-77 (2001)
Early goal-directed therapy in the treatment of severe sepsis and septic shock.
E Rivers
,
B Nguyen
,
S Havstad
,
J Ressler
,
A Muzzin
,
B Knoblich
,
E Peterson
,
M Tomlanovich
,
Early Goal-Directed Therapy Collaborative Group
ABSTRACT
Goal-directed therapy has been used for severe sepsis and septic shock in the intensive care unit. This approach involves adjustments of cardiac preload, afterload, and contractility to balance oxygen delivery with oxygen demand. The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit.