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(Journal Article) |
Journal of hypertension 33 (3): 627-33 (2015)
Thiazide-induced hyponatraemia is associated with increased water intake and impaired urea-mediated water excretion at low plasma antidiuretic hormone and urine aquaporin-2.
Nanne J. Frenkel
,
Liffert Vogt
,
Sophia E. De Rooij
,
Christiane Trimpert
,
Marcel M. Levi
,
Peter M.T. Deen
,
Bert-Jan H. van den Born
ABSTRACT
Hyponatraemia is a common, potentially life-threatening, complication of thiazide diuretics. The mechanism of thiazide-induced hyponatraemia is incompletely understood. Previous experiments have suggested a direct effect of thiazide diuretics on the plasma membrane expression of aquaporin (AQP)2.