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(Journal Article) |
Nutrition 45: 99-103 (2018)
The risk for hypoglycemia during Ramadan fasting in patients with adrenal insufficiency
M Chihaoui
,
W Grira
,
J Bettaieb
,
M Yazidi
,
F Chaker
,
O Rejeb
,
I Oueslati
,
M Feki
,
N Kaabachi
,
H Slimane
ABSTRACT
Objectives The risk for hypoglycemia during Ramadan fasting in patients with adrenal insufficiency (AI) is not fully known. The aims of this study were to evaluate this risk objectively and to determine the associated factors. Methods This prospective case-crossover study included 25 women and 5 men with known and treated AI and a median age of 38.5 y. Patients underwent clinical examination and a fasting blood sample was collected to measure glucose, urea, creatinine, sodium, potassium, cortisol, growth hormone and free thyroxine. A 24-h continuous glucose monitoring system (CGMS) using iPro2 (Medtronic, Parsippany, NJ, USA) with Enlite sensor (Medtronic) was performed for each patient during a Ramadan fasting day then again during a nonfasting day. Results Interstitial glucose levels during the 24-h period, the fasting period, and the fasting period after exclusion of the 5 postprandial hours were significantly lower during the fasting day than on the nonfasting day. Hypoglycemia occurred in three patients (10%) during the fasting day but not during the nonfasting day (P = 0.23). Hypoglycemia was asymptomatic in two cases. Male sex was significantly associated with the occurrence of hypoglycemia. Conclusion Interstitial glucose levels were lower during fasting in patients with AI. However, the risk for hypoglycemia was not increased. © 2017 Elsevier Inc.
Notes
Export Date: 11 December 2017