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(Journal Article) |
Microbes and infection 2 (13): 1567-78 (2000)
Diagnosis of defects in the type 1 cytokine pathway.
D A Lammas
,
P Drysdale
,
A Ben-Smith
,
J Girdlestone
,
D Edgar
,
D S Kumararatne
ABSTRACT
Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.