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(Journal Article) |
British journal of haematology 116 (2): 497-9 (2002)
Non-myeloablative bone marrow transplantation in an adult with Wiskott-Aldrich syndrome.
Hilary J Longhurst
,
David Taussig
,
Tanzina Haque
,
Denise Syndercombe-Court
,
Jamie Cavenagh
,
J David Edgar
,
Matthew R Helbert
ABSTRACT
Early bone marrow transplant is now standard treatment for infants with severe immunodeficiencies such as Wiskott-Aldrich Syndrome (WAS), but results in older children and adults are poor. Non-myeloablative transplant has shown promise in the treatment of older children, who are likely to have active infections and organ damage. We describe a non-myeloablative transplant of a 26-year-old man with WAS, undertaken because of severe infections and vasculitis. Partial engraftment and immunorestoration were achieved. The patient is well 1 year post transplantation.