| Updated in 2/1/2022 3:50:13 PM |
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(Journal Article) |
Nutrition reviews 79 (2): 200-208 (2021)
Supplementation with vitamin D in the COVID-19 pandemic?
Fatemeh Hadizadeh
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic was declared a public health emergency of international concern by the World Health Organization. COVID-19 has high transmissibility and could result in acute lung injury in a fraction of patients. By counterbalancing the activity of the renin-angiotensin system, angiotensin-converting enzyme 2, which is the fusion receptor of the virus, plays a protective role against the development of complications of this viral infection. Vitamin?D can induce the expression of angiotensin-converting enzyme 2 and regulate the immune system through different mechanisms. Epidemiologic studies of the relationship between vitamin?D and various respiratory infections were reviewed and, here, the postulated mechanisms and clinical data supporting the protective role of vitamin?D against COVID-19-mediated complications are discussed.