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(Journal Article) |
One-Pot Approach to Chiral Chromenes via Enantioselective Organocatalytic Domino Oxa-Michael—Aldol Reaction.
H Li
,
J Wang
,
T E-Nunu
,
L Zu
,
W Jiang
ABSTRACT
A highly enantioselective (S)-diphenylpyrrolinol triethylsilyl ether promoted tandem oxa-Michael–aldol reaction of α,β-unsaturated aldehydes with salicylaldehydes has been developed; the method affords one-pot access to chiral and synthetically useful chromenes in high yields and high enantioselectivities from readily available compounds.